抑郁与帕金森病
2018年08月06日 【健康号】 梁志刚

目的:该研究的目的是评价台湾全民健康保险研究资料库(NHIRD)中抑郁患者发生帕金森病的发病风险情况。

Methods: We conducted a retrospective study of a matched cohort of 23,180 participants (4,634 patients with depression and 18,544 control patients) who were selected from the NHIRD. Patients were observed for a maximum of 10 years to determine the rates of new-onset PD, and Cox regression was used to identify the predictors of PD. We also examined the risk of PD after excluding patients who were diagnosed with PD within 2 or 5 years after their depression diagnosis. A logistic regression model was used to identify risk factors associated with PD onset in patients with depression. 
方法:该研究为回顾性研究,纳入人群为NHIRD库中匹配的23180例参与者,其中4634例抑郁患者,18544例对照患者。最长随访时间为10年,评估新发帕金森病的发生率,使用Cox回归分析预测帕金森病的危险因素。同时排除已诊断为抑郁的患者2到5年内发生帕金森病的患者后,评估首次诊断为帕金森病的发病情况。利用logistic回归模型分析抑郁患者发生帕金森病的危险因素。

Results: During the 10-year follow-up period, 66 patients with depression (1.42%) and 97 control patients (0.52%) were diagnosed with PD. After adjusting for age and sex, patients with depression were 3.24 times more likely to develop PD (95% confidence interval 2.36–4.44, p < 0.001) compared with the control patients. After excluding patients who were diagnosed with PD within 2 or 5 years after their depression diagnosis, patients with depression had a higher hazard ratio for developing PD than the control patients. The odds ratios for age (1.09) and difficult-to-treat depression (2.18) showed that each is an independent risk factor for PD in patients with depression. 
结果:在10年的随同期内,抑郁患者中有66例(1.42%)出现帕金森病,对照组中97例(0.52%)出现帕金森病。在调整年龄和性别后,与对照组相比,抑郁患者发生帕金森病的可能性是对照组人群的3.24倍。在排除抑郁患者中2到5年内发生帕金森病的患者后,抑郁患者相比对照人群发生帕金森病的危险比更高。回归分析显示年龄和难治疗的抑郁两项因素是抑郁患者发生帕金森病的独立危险因素。

Conclusion: The likelihood of developing PD is greater among patients with depression than patients without depression. Depression may be an independent risk factor for PD. 
结论:抑郁患者发展为帕金森病的可能性较无抑郁的患者明显增加。抑郁或为帕金森病的独立危险因素。    


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梁志刚
副主任医师/副教授
脑血管病急性期诊治,脑卒中规范二级一级预防,脑卒中临床研究,脑卒中急性期血管再通治疗。帕金... 更多
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