最新医学研究发现预测肝癌手术切除以后复发转移的预测新指...
2018年07月12日 【健康号】 李涛     阅读 4066

最新一期国际著名杂志Nature子刊Scientific reports (IF:5.6)发表了山东大学齐鲁医院肝胆外科李涛副主任医师的临床研究论文。李涛副主任医师针对新发现的癌基因TMPRSS4进一步研究其在肝癌侵袭,转移及复发中的作用,发现TMPRSS4通过激活Raf/MEK/ERK1/2信号通路诱导肝癌细胞的上皮间质转化,从而促进肝癌的复发转移。李涛副主任医师结合手术切除的398例肝癌患者的病理资料,发现TMPRSS4高表达的肝癌患者肿瘤侵袭性强,患者术后容易发生早期复发和远处转移,预后差,因此对于TMPRSS4阳性表达的肝癌患者术后应加强密切随访并采取相应的辅助治疗以减少术后复发转移,提高肝癌患者的预后。该研究为判断肝癌患者手术切除后的预后具有重要意义。山东大学齐鲁医院肝胆外科李涛

Sci Rep. 2015 Jul 20;5:12366. doi: 10.1038/srep12366.

TMPRSS4 facilitates epithelial-mesenchymal transition of hepatocellular carcinoma and is a predictive marker for poor prognosis of patients after curative resection.

Li T

Author information

Abstract

TMPRSS4 (Transmembrane protease serine 4) is up-regulated in a broad spectrum of cancers. However, little is known about the biological effects of TMPRSS4 on hepatocellular carcinoma (HCC) and the related mechanisms. In the present study, we found that overexpression of TMPRSS4 significantly promoted the invasion, migration, adhesion and metastasis of HCC. Further more, TMPRSS4 induced EMT of HCC, which was mediated via snail and slug as a result of Raf/MEK/ERK1/2 activation, and inhibition of ERK1/2 activation by its inhibitor was associated with reduced cell invasion and reversion of EMT. In addition, we demonstrated that TMPRSS4 remarkably suppressed the expression of RECK, an inhibitor of angiogenesis, and drastically induced tumor angiogenesis and growth. More important, in clinical HCC specimens, TMPRSS4 expression was significantly correlated with tumor staging and was inversely correlated with E-cadherin and RECKS expression. Expression of TMPRSS4 is significantly associated with HCC progression and is an independent prognostic factor for postoperative worse survival and recurrence. In conclusion, TMPRSS4 functions as a positive regulator of Raf/MEK/ERK1/2 pathway and promotes HCC progression by inducing EMT and angiogenesis. The increase of TMPRSS4 expression may be a key event for HCC progression and may be regarded as a potential prognostic marker for HCC.

  • PMID:

  • 26190376


  • [PubMed - in process] 


  • PMCID:


  • PMC4507176






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李涛
主任医师/教授
山东大学齐鲁医院
肝胆外科,普外科
普外肝胆,胰腺,胃肠及腹腔镜微创手术。
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