在2018年,狼疮中肠道的菌群的角色,我们有知道多少?
2019年01月17日 【健康号】 吴振彪     阅读 8549

翻译者:赵倩倩,西京医院临床免疫科

人类肠道微生物群在维持健康生理状况中的作用以及其与疾病发展的关系仍有待澄清。

目前的证据表明,肠道微生物可能参与自身免疫性疾病的发生和发展,包括类风湿关节炎和系统性红斑狼疮(SLE)。

尽管最近在了解这些微生物如何影响狼疮的病理生理学方面取得了进展,但研究仍然有限。

涵盖的领域:

在这篇综述中,我们试图总结最相关的研究结果,这些研究结果有助于我们理解人类肠道微生物群与狼疮发展之间的联系。我们还描述了个体微生物参与者在狼疮生理学中的潜在作用,以及它们如何塑造相关的免疫反应。

专家评论:

基于大规模测序的独立于培养的技术是解开肠道微生物生物活性的有力工具。目前的数据表明,根据肠道微生物的模式或特定细菌的存在,可以触发与狼疮生理学相关的不同反应。 粪便微生物群移植,活体生物治疗或针对微生物群的饮食干预可能会成为SLE的治疗方法。

参考文献:

The role of gut microbiota in lupus: what we knowin 2018?

The role of the human intestinalmicrobiota in the maintenance of a healthy physiological condition, as well asits relation to the development of disease, remains to be clarified. Currentevidence suggests that intestinal microbes could be involved in the initiationand amplification of autoimmune diseases, including rheumatoid arthritis and systemiclupus erythematosus (SLE). Despite recent progress in understanding how thesemicrobes influence the pathophysiology of lupus, studies are still limited.Areas covered: In this review, we have tried to summarize the most relevantfindings that have contributed to our understanding of the links between thehuman intestinal microbiota and the development of lupus. We also describe thepotential role of individual microbial players in the physiology of lupus, andhow they can shape relevant immune responses. Expert commentary:Culture-independent techniques based on massive sequencing represent a powerfultool to unravel the biological activity of gut microbes. Current datademonstrates that, depending on the pattern of intestinal microorganisms or thepresence of specific bacteria, different responses related to lupus physiologycan be triggered. Fecal microbiota transplantation, live biotherapeutics, ordietary interventions targeting the microbiota will likely become a treatmentfor SLE.

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吴振彪
主任医师/教授
唐都医院
风湿免疫科,风湿免疫...
对疑难危重风湿病如系统性红斑狼疮,类风湿关节炎,脊柱关节炎,血管炎,干燥综合征,系统性硬化... 更多
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